spleen tyrosine kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16776	RO9021		Syk
	RO9021 is an orally bioavailable, novel ATP-competitive SYK inhibitor (average IC50: 5.6 nM).		Syk
T4209	TAK-659 hydrochloride	TAK-659	VEGFR , FLT , Tyrosine Kinases , JAK , Syk
	TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.		VEGFR , FLT , Tyrosine Kinases , JAK , Syk
T39437	Cevidoplenib dimesylate		Syk
	Cevidoplenib dimesylate is an inhibitor of spleen tyrosine kinase (Syk), possessing anti-inflammatory and immunomodulating properties.		Syk
T14331	Gusacitinib	ASN-002	JAK , Syk
	Gusacitinib (ASN-002) (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).		JAK , Syk
T11824LL	Lanraplenib	GS-9876	Syk
	Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) in development for the treatment of inflammatory diseases. Lanraplenib inhibits SYK activity in platelets via the glycoprotein VI ...		Syk
T6101	Entospletinib	GS-9973	Syk
	Entospletinib (GS-9973) (IC50= 7.7 nM)is a specific Syk inhibitor, which is orally bioavailable.		Syk
T6115	Fostamatinib	R788	FLT , Syk , Monoamine Transporter , Adenosine Receptor
	Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.		FLT , Syk , Monoamine Transporter , Adenosine Receptor
T6594	MNS		Syk , Src , p97
	MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.		Syk , Src , p97
T6174	R406	R-406 besylate	Apoptosis , FLT , Syk
	R406 (R-406 besylate) is an effective Syk inhibitor (IC50: 41 nM) and shows no effects on Lyn.		Apoptosis , FLT , Syk
T4348	Syk Inhibitor II		5-HT Receptor , Syk
	Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).		5-HT Receptor , Syk
T2467	R406 free base	R406 (free base)	Apoptosis , FLT , Syk
	R406 free base (R406 (free base)) is a potent Syk inhibitor.		Apoptosis , FLT , Syk
T0610	Piceatannol	trans-Piceatannol,Astringenin	Apoptosis , Serine/threonin kinase , PKA , Syk , PKC , Autophagy
	Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is...
T2487	Cerdulatinib	PRT2070,PRT062070	Tyrosine Kinases , JAK , Syk
	Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.		Tyrosine Kinases , JAK , Syk
T3185	R112	(E)-Elafibranor	Syk
	R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase.		Syk
T2605	Fostamatinib Disodium	Tamatinib Fosdium,R788(Disodium),R788 Disodium,R788 (Fostamatinib) Disodium	FLT , Syk
	Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.		FLT , Syk
T6776	BAY 61-3606 dihydrochloride	BAY 61-3606,BAY-61-3606 dihydrochloride	Apoptosis , Syk
	BAY 61-3606 dihydrochloride (BAY 61-3606) is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).		Apoptosis , Syk
T6957	PRT-060318	P142-76,PRT318,PRT-060318 2HCl	Syk
	PRT-060318 (P142-76) is a novel selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.		Syk
T2696	PRT062607 hydrochloride	PRT062607 (P505-15, BIIB057) HCl,P505-15 Hydrochloride	MLK , Syk , Src
	PRT062607 hydrochloride (P505-15 Hydrochloride) is a selective inhibitor of Syk (IC50: 1 nM). It displays at least 80-fold selectivity for Syk over other kinases.		MLK , Syk , Src
T4263	BAY 61-3606	Syk inhibitor IV	Apoptosis , Syk
	BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.		Apoptosis , Syk
T6104	Cerdulatinib hydrochloride	Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride	MLK , c-Fms , Tyrosine Kinases , Hippo pathway , JAK , Syk
	Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19...		MLK , c-Fms , Tyrosine Kinases , Hippo pathway , JAK , Syk